Every minute matters in an opioid overdose. Naloxone, the medication that reverses opioid overdose, can restore normal breathing within 2 to 3 minutes, but during an overdose breathing can slow or stop entirely, so acting fast is critical. According to the CDC, a potential bystander was present in nearly 43% of overdose deaths in 2023. In other words, someone was often there who could have helped, but many people who witness an overdose have never been trained, don’t know where the naloxone is, and freeze in the critical window when action could save a life. The ONEbox® was designed to solve exactly that problem: getting training to the person who needs it when they need it, even if they’ve never held a naloxone kit before.
What Is the ONEbox®?
The ONEbox® is an emergency kit for reversing opioid overdoses. It was developed band invented by Joe Murphy, CEO of by Murphy Media, Inc. and is now owned and managed by Rapid, Risk, Reduction (R3). The idea is simple: place a kit wherever an overdose might happen, so that anyone nearby can get clear, step-by-step guidance the moment they need it, even if they have no training.
What makes the ONEbox® different is the guidance built right into it. The flagship (Classic) version has a small video screen that plays two videos: a 1-minute emergency video in English and Spanish that walks a bystander through what to do during an overdose, and a longer 5-minute video that staff or community members can watch ahead of time to learn how to give naloxone. A lower-cost version (the Flex Box) uses a QR code that opens the same emergency video on a phone instead of a built-in screen. A third version, the Co-Location Kit contains the video and is intended to be placed inside or alongside AED devices along with naloxone. Finally, the colocation version, which is a smaller, video focused naloxone training device, allows for the necessary training/education to be placed directly inside systems that are pre-established mechanisms for first response (I.E. AED cabinets, wall mounts, and indoor/outdoor naloxone vending machines).
The box does not come with naloxone. You add your own, and the kit holds all brands of naloxone, along with protective equipment (such as gloves) for the person responding.
The ONEbox® has been featured by CBS News, NPR, and Bloomberg, and has been used by universities, K-12 school systems, libraries, homeless shelters, law enforcement agencies, sports arenas, county governments, non-profits and healthcare organizations around the country.
The Problem the ONEbox® Addresses
The opioid crisis has made naloxone one of the most important public health tools in the United States. Naloxone is safe, effective, and increasingly available, but availability alone is not enough. The gap between having naloxone present in a building and having it successfully administered during an overdose is filled with human factors: confusion, fear, uncertainty about what to do, and the absence of training in the very moment it is needed most.
Traditional naloxone training programs require people to attend a class or watch a video in advance, and to retain that information until the day it is needed, which could be months or years later. Many people who witness an overdose have no prior training at all. The ONEbox® addresses this by delivering training at the point of need, not weeks before, but in the moment, on-screen, exactly where the naloxone is stored.
Three ONEbox® Versions for Every Setting
ONEbox® Classic: $179.99
The flagship product. A sturdy, lightweight box that can be mounted on a wall or carried where it’s needed. It contains:
- 3 pieces of protective equipment (such as gloves) for the responder
- A video screen that plays the 1-minute emergency video, in English and Spanish, for use during an overdose
- A longer 5-minute training video so staff and community members can learn how to give naloxone ahead of time
- A tagging system to help track and restock supplies
- A charging cord
- Room to store your own naloxone
ONEbox® Colocation: $129.99
The Colocation kit is built to attach to safety equipment you already have, using double-stick tape. It can go on vending machines, AEDs (the devices used to restart a heart), fire extinguishers, first aid kits, and other overdose response boxes. It includes:
- A video screen that plays the 1-minute emergency video in English and Spanish
- The 5-minute training video
- 2 pieces of protective equipment
- A charging cord
This version makes the most of safety equipment that’s already in place. An organization that already has AEDs or first aid stations can add overdose response without needing a separate spot to mount a full box.
ONEbox® Flex: $50
The most affordable option. Instead of a built-in screen, the Flex uses a QR code that opens the same emergency video on a phone. It can be mounted or carried, and it includes:
- 3 pieces of protective equipment
- Written instructions
- A tagging system to help track and restock supplies
- A setup and maintenance guide
- An optional add-on to include the video screen
Prices are current as of the WVDII ONEbox page and may change.
How the ONEbox® Works
Emergency Response Mode
During an active overdose, the 1-minute bilingual emergency instruction video provides step-by-step on-screen guidance for a bystander who has never administered naloxone before. The video walks the responder through recognizing overdose signs, accessing the naloxone, administering it correctly, and taking appropriate next steps including calling 911. This is training at the moment it is needed, requiring no prior knowledge from the person responding.
Training Mode
The 5+ minute training video allows staff, students, residents, and community members to learn naloxone administration before an emergency occurs. Organizations can use the ONEbox® as a self-contained training station with no instructor or advance scheduling required. Training happens where the box is deployed, reinforcing both the knowledge and the location of the naloxone.
Find the Purple Box
The ONEbox®’s purple color makes it easy to spot. When people know what the box looks like and where it is located, response time decreases. The “Find the Purple Box” positioning builds community familiarity with the ONEbox® the same way years of public health campaigns have built familiarity with the red AED cabinet.
Where the ONEbox® Has Been Deployed
The ONEbox® has been adopted across a wide range of settings that reflect the breadth of the opioid crisis’s reach:
- Collegiate campuses: Universities including West Virginia University and Clemson University have deployed the ONEbox® across campus buildings, dormitories, and athletic facilities
- K-12 Schools: Wilson County (NC) & Nash County (NC) have adopted the ONEbox(R) across elementary, middle, and high school campuses, as well as on all school funded transportation methods (buses)
- Public libraries: Library systems have adopted the ONEbox® as part of their harm reduction and community health programming
- Homeless shelters: Organizations like Harmony House have placed the ONEbox® in facilities where overdose risk is particularly high and trained staff may not always be immediately available
- Law enforcement: Police departments have integrated the ONEbox® into stations and patrol vehicles to ensure immediate response capability
- County governments: Wilson County, NC has been cited as a model for how county-level adoption can systematically expand overdose response infrastructure across a community
- Healthcare and community organizations: Partners including OVP Health and Gibson Gives have used the ONEbox® to extend naloxone access beyond traditional clinical settings
Why On-Demand Training Matters
The traditional model of naloxone training has a fundamental flaw: it front-loads the intervention. A person attends a training, learns how to administer naloxone, and then may not encounter an overdose for months or years, if ever. By that time, the specifics of what to do may have faded. Worse, many people who witness overdoses receive no formal training at all.
The ONEbox® inverts this model. Instead of training people and then deploying equipment, it deploys the training alongside the equipment, ensuring that anyone who picks up the box has immediate access to the instruction they need. This follows the same model used for AEDs in cardiac arrest response: combining the device with on-device instruction so that even an untrained bystander can respond effectively.
For organizations navigating limited staff time, high turnover, or geographically dispersed locations, the ONEbox® removes the dependency on a trained person being present. The training lives in the box.
Getting Started: Setup Is Simple
The ONEbox® arrives fully configured. Setup requires one step: just add naloxone. There is no software to install and no technical expertise required. The product includes a Quick Start Guides and Standard Operating Procedures for all three models directly on their website.
R3 offers tax-exempt ordering and discounted pricing for nonprofit and qualifying organizations. For current nonprofit pricing, or questions about larger deployments and partnerships, the R3 team can be reached directly through their website.
The Bigger Picture: Naloxone Access as Public Health Infrastructure
The opioid overdose crisis kills tens of thousands of Americans every year. Many of those deaths happen outside of healthcare settings, in homes, public spaces, workplaces, and community environments where clinical staff are not present. Naloxone works. Programs that train community members and distribute naloxone have been shown to reduce overdose deaths: according to the CDC, one Massachusetts study found a 46% drop in opioid overdose deaths in communities that enrolled enough people in these programs. The limiting factor is not the existence of the medication, it is the gap between where naloxone exists and whether the person who finds someone in overdose knows what to do with it.
The ONEbox® is a piece of public health infrastructure designed for exactly this gap. It does not require a clinician or prior training, and it guides the person responding through every step. In a crisis where seconds matter, that combination of accessibility and on-demand instruction can make the difference between reaching someone in time and not.
Learn More and Get Involved
The ONEbox® is available at: https://oneboxready.com/. All three versions, Classic, Co-Locate, and Flex, can be requested by organizations looking to expand overdose response capability in their communities. Free resources including Quick Start Guides and use case videos are available at www.rthree.io or can be directly requested by contacting Rapid Risk Reduction directly at support@rthree.io.
Whether you are a university administrator, a library director, a shelter operator, a law enforcement agency, or a public health official, the ONEbox® offers a simple way to help ensure that naloxone is present and that someone nearby can use it when the moment arrives. Organizations interested in deploying the ONEbox® can learn more or get in touch with the R3 team through their website.
The ONEbox® keeps people alive in the critical window when action matters most. Staying alive is what makes recovery possible, and for anyone ready to take that next step, effective treatment for opioid use disorder is available
.